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KMID : 0380020200350020162
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Korean Journal of Biotechnology and Bioengineering
2020 Volume.35 No. 2 p.162 ~ p.168
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Anti-inflammatory Effect of Colocasia esculenta Biorenovate Extract in LPS-stimulated RAW 264.7 Cells
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Park Tae-Jin
Sim Ji-Han
Hong Hye-Hyun
Han Dong-Hwan
Kim Seung-Young
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Abstract
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Biorenovation is a method of modifying the structure of a broad range of substrates such as chemical compounds and plant extract by microbial enzymes with the potential benefits of reduced cytotoxicities and enhanced biological activities relative to its parent substrates. We generated Colocasia esculenta L. Schott root extract using Biorenovation technology and tested the anti-inflammatory properties of its Biorenovation product (CEB) in lipopolysaccharide (LPS)-treated RAW264.7 murine macrophages. CEB inhibited the LPS-induced production of pro-inflammatory markers such as nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) in a concentration dependent manner without no noticeable toxicities in RAW 264.7 cells. Then together, our results indicate that CEB could be a new source for the ingredients of cosmetics and pharmaceuticals.
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KEYWORD
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anti-inflammation, Bio-renovation, COX-2, iNOS, Colocasia esculenta L. Schott
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